Perfloxacin is a fluoroquinolone antibiotic and is an analog of norfloxacin. It targets gram-negative and gram-positive bacteria as well as several Mycoplasma species. It is commonly used against Gonococcal species and to induce achilles tendon toxicity in rodents.
Fluoroquinolones are a group of broad-spectrum antibiotics that inhibit DNA synthesis. These antibiotics prevent unwinding of double-stranded DNA by binding DNA gyrase or DNA topoisomerase. By preventing the formation of single-stranded DNA, fluoroquinolones inhibit bacterial replication.
